Home Chemistry Heterocyclic Building Blocks Pyrazines 5H-Pyrrolo[2,3-B]Pyrazine
Electrophilic Aromatic Substitution (EAS): If there are electron-rich groups on the molecule, it can undergo EAS reactions. For example, if there are electron-donating groups (such as alkyl groups) attached, the pyrrolo-pyrazine ring can undergo substitution reactions with electrophiles.
Nucleophilic Aromatic Substitution (NAS): If there are electron-withdrawing groups on the molecule, it can undergo NAS reactions. This involves substitution reactions where a nucleophile replaces a leaving group on the aromatic ring.
Reduction: The pyrrolo-pyrazine ring can potentially be reduced to yield a dihydro derivative. This can be achieved using reducing agents like hydrogen gas and a suitable catalyst.
Oxidation: Depending on the substituents, oxidation reactions can be carried out. This could lead to the formation of N-oxides or other oxidation products.
Ring Opening Reactions: Under certain conditions, the ring structure might be susceptible to ring-opening reactions, potentially forming linear or more open-chain compounds.
Substitution Reactions: Depending on the functional groups attached to the pyrrolo-pyrazine ring, various substitution reactions can occur. This might involve the replacement of a functional group with another group.
Cyclization Reactions: If there are suitable functional groups present, additional cyclization reactions can occur, potentially leading to more complex ring systems.
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2-Bromo-5H-pyrrolo[2,3-b]pyrazine-7-carbaldehyde
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2-Chloro-7-iodo-5H-pyrrolo[2,3-b]pyrazine
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2-Bromo-3-methyl-5H-pyrrolo[2,3-b]pyrazine
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2-Bromo-7-nitro-5H-pyrrolo[2,3-b]pyrazine
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5H-Pyrrolo[2,3-b]pyrazine-6-carboxylic acid
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